Cell migration is a fundamental process that involves the coordination of complex biochemical and biomechanical signals to modulate cell morphology by dynamically rearranging cytoskeleton filaments and to cause cellular traction. Slight alteration in this tightly regulated process in a cell could result in a wide variety of pathologies including metastasis of cancer cells.
More than 200 proteins are known to be involved in this dynamic process. A new study from University of Connecticut identifies crucial role for a novel protein CD13 in cell to extracellular matrix (ECM) adhesion. This study demonstrates that CD13 controls integrin recycling a major protein family responsible for cellular migration.
https://stke.sciencemag.org/content/12/579/eaav5938?utm_campaign=toc_signaling_2019-04-30&et_rid=17082276&et_cid=2793732
https://stke.sciencemag.org/content/12/579/eaav5938?utm_campaign=toc_signaling_2019-04-30&et_rid=17082276&et_cid=2793732
